UN Commission approves WHO suggestions to position psychoactive substances below worldwide management

UN Commission approves WHO suggestions to position psychoactive substances below worldwide management

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Following suggestions by the World Health Organization (WHO), the United Nations Commission on Narcotic Drugs (CND) has determined to position 5 new psychoactive substances and one drugs below worldwide management.

The suggestions had been developed by WHO Expert Committee on Drug Dependence–ECDD, which consists of world specialists analyzing well being dangers and advantages of psychoactive substances circulating on international markets and alerting to incorporate them below worldwide management if proof discovered that their use could cause hurt for inhabitants well being in international locations.



“These substances have been brought to WHO’s attention for being clandestinely manufactured, posing serious risk to public health and society without any recognized therapeutic use,” stated Dr Deus Mubangizi, WHO Director for Health Product Policy and Standards. “We are pleased that the Commission (on Narcotic Drugs) has accepted the full set of WHO recommendations and added these substances to relevant schedules in the 1961 or 1971 Conventions. We hope countries and communities will increase vigilance and take necessary actions to protect vulnerable groups particularly youth from these substances.”

Four substances positioned in Schedule I of the Single Convention on Narcotic Drugs (1961), as amended by the 1972 Protocol are:

  • N-Pyrrolidino protonitazene, additionally known as protonitazepyne, is an artificial opioid.  It has been described as a beige powder or a white colourless or crystalline strong, and has been recognized in falsified pharmaceutical opioid tablets. It is reported to be administered by numerous routes, together with smoking, snorting and by injection. It could cause substantial hurt, together with dying. It has no recognized therapeutic use.
  • N-Pyrrolidino metonitazene, additionally known as metonitazepyne, is an artificial opioid. It has been described as a beige powder and is reported to be administered by injection. There is proof that its use causes substantial hurt, together with dying. It has no recognized therapeutic use.
  • Etonitazepipne, additionally known as N-piperidinyl etonitazene, is an artificial opioid.  It has been described as a crystalline strong and a yellowish-white or yellow powder. There is proof that use of this substance causes substantial hurt, together with dying. It has no recognized therapeutic use.
  • N-Desethyl isotonitazene, additionally known as norisotonitazene, is an artificial opioid that has been described as a crystalline strong. It has been recognized in falsified prescribed drugs. Multiple deaths and hospital admissions have been reported in at the least two areas. There is proof that its use causes substantial hurt, together with dying. It has no recognized therapeutic use.
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    Substance positioned in Schedule II of the Convention on Psychotropic Substances (1971):

  • Hexahydrocannabinol, also referred to as HHC, is a semi-synthetic cannabinoid described as a colourless viscous oil or resin. Products reminiscent of THC hashish flowers and resins infused or sprayed with the substance, e-liquids and cartridges for digital cigarettes, edible merchandise reminiscent of gummies and marshmallows, tinctures resembling dietary dietary supplements and distillate oils can embrace HHC. There is enough proof that HHC is utilized in methods to represent a public well being and social downside, warranting placement below worldwide management.

    • Substance positioned in Schedule IV of the Convention on Psychotropic Substances (1971):

  • Carisoprodol is a centrally appearing skeletal muscle relaxant offered as a single-ingredient preparation and together merchandise. Carisoprodol is on the market as a pharmaceutical product in pill kind, has been detected in falsified prescribed drugs and can be discovered as a white powder. There is growing proof that nonmedical use of carisoprodol in plenty of international locations constitutes a big threat to public well being.

    • WHO has been convening the ECDD as a scientific advisory physique for over 70 years with the mission to guard populations from dangerous substances and to make sure that psychoactive substances can be found the place wanted for medical and scientific functions. The ECDD conducts scientific evaluations on the request of the UN Commission on Narcotic Drugs and is the one treaty-mandated physique to supply well being suggestions to the Commission to tell selections in drug coverage.

    With the continued emergence of extra dangerous substances, together with clandestinely manufactured artificial opioids with no medical use reminiscent of fentanyl and nitazenes, Member States expressed curiosity in additional scientific evaluations of those substances by WHO within the coming interval. Above-mentioned selections had been introduced on the 68th common session of the Commission on Narcotic Drugs, happening in Vienna, Austria, on 10-14 March 2025. 

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    Sourced from WHO

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